Nerve growth factor (NGF) is one of the key drivers of chronic osteoarthritis pain*,1
The role of NGF in the peripheral pain pathway
Biochemical mediators in the periphery
Biochemical mediators in the periphery
Understanding chronic pain

*NGF and other biochemical mediators, including IL-1β, PGE2, IL-6, and TNFα, play an important role in the pain pathway.1-4 The inhibition of NGF is an area of study in patients with chronic OA pain.1

IL=interleukin; NGF=nerve growth factor; PGE=prostaglandin; TNF=tumor necrosis factor.

References: 1. Mantyh PW, et al. Anesthesiology. 2011;115:189-204. 2. McGreevy K, et al. Eur J Pain Suppl. 2011;5:365-372. 3. National Pharmaceutical Council; Joint Commission on Accreditation of Healthcare Organizations.
http://www.npcnow.org/publication/pain-currentunderstanding-assessment-management-and-treatments. Accessed June 16, 2020. 4. Breivik H, et al. Eur J Pain. 2006;10:287-333

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