*NGF and other biochemical mediators, including IL-1β, PGE2, IL-6, and TNFα, play an important role in the pain pathway.1-4 The inhibition of NGF is an area of study in patients with chronic OA pain.1
IL=interleukin; NGF=nerve growth factor; PGE=prostaglandin; TNF=tumor necrosis factor.
References: 1. Mantyh PW, et al.
McGreevy K, et al.
Eur J Pain Suppl. 2011;5:365-372. 3. National Pharmaceutical
Council; Joint Commission on Accreditation of Healthcare Organizations.
http://www.npcnow.org/publication/pain-currentunderstanding-assessment-management-and-treatments. Accessed June 16, 2020. 4. Breivik H, et al. Eur J Pain. 2006;10:287-333